Assessment of the antiurolithiatic effect of Parmentiera aculeata fruit on Wistar rat
Diuretic and antiurolithiatic activities of hexane, chloroform, methanol and aqueous extracts of Parmentiera aculeata (Kunth) Seem. (Bignoniaceae) were evaluated. The formation of bladder stones was induced surgically placing a magnesium plate in male Wistar rats (250 g). After 28 days the presence of bladder stones was corroborated by radiological plates. We performed a subchronic assay for 28 days and the animals were grouped as follow: water (control), positive control (furosemide, 0.25 mg kg -1 day-1) and 2 mL each plant extract (70 mg kg-1 day-1). The values of water consumed and urine excreted at different times were significantly greater with furosemide, as well as they were in methanol and hexane extracts. In general, urine production correlated positively with increased water consumption. The chloroform extract induced the most weight of the bladder stones (P = 0.0228) and the mean stone weight of hexane, methanol and aqueous extracts respect to the negative control did not have significant differences. It was observed bladder stone fragmentation with hexane and methanol extracts; this is an important aspect that could facilitate its elimination through urine. These results confirm the use of P. aculeata in the folk medicine against urolithiasis.
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